Duration of action of beta-blocking drugs.

Pharmacological properties of beta-adrenoceptor blocking drugs

Report on Round Table on renin suppression and the hypotensive action of beta-adrenergic-blocking drugs.

ROBERTSON: We have this morning rather a large Round Table, with ten speakers, all of whom have been promised that they will get at least one chance to speak. Also quite a number of people in the audience have indicated to me that they wish to join in. Unfortunately, we are limited to 1 h. It is my job as Chairman to try to reconcile some of these obviously irreconcilable objectives and we shal...

New approach to assessment of cardioselectivity of beta-blocking drugs.

Propranolol, practolol, and placebo were each given intravenously at weekly intervals to six normal subjects, and their effects on respiratory function tests and heart rates assessed. The reduction in the exercise heart rate after each of the two drugs was most comparable at six hours, indicating a similar degree of cardiac beta-blockade, when the plasma concentration ratio of practolol to prop...

Effects of propranolol on the action of neuromuscular blocking drugs.

The use of propranolol in the treatment of arrhythmias during anaesthesia has recently been discussed by Vickers (1966). After intra-arterial injection of comparatively large doses, propranolol, like the structurally related pronethalol (Tiirker and Kiran, 1965), augments the action of neuromuscular blocking agents (Wislicki and Rosenblum, 1967). It has been shown that propranolol not only bloc...

Beta-adrenergic blocking drugs in the treatment of hypertension.

The reduction in blood pressure seen with the use of beta-blocking drugs was an unexpected finding. Initially there was resistance to their use as the reduction of cardiac output and increase in peripheral resistance from beta-blockade was considered an undesirable pharmacological action for a drug in the treatment of hypertension. However, beta-blockers have now become established in the treat...